Here, we explore the expression of CK2 transcripts in primary tumor tissues using the database Oncomine in the six cancers with the highest mortality in the U.S.A. However, we have little information on CK2α' and CK2β proteins, and scarce information on CK2 gene transcript expression. CK2, typically the CK2α protein, is found elevated in a number of human tumors. CK2 functions as an oncogene when overexpressed in mouse tissues, and can synergize with known oncogenes, such as ras, to induce cell transformation in cells in culture. CK2 is a serine-threonine kinase that has been involved in cell growth, cell proliferation and cell apoptosis. A protein historically involved in cancer is protein kinase CK2. Cancer cells proliferate uncontrollably and, many cases, spread to other parts of the body. Cancer is a leading cause of death worldwide.
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